VIP (VASOACTIVE INTESTINAL PEPTIDE) INJECTOR PEN 3ML

VIP (Vasoactive Intestinal Peptide): The Master Neuroimmune Regulator for Systemic Anti-Inflammatory, Cardiopulmonary, and Homeostatic Balance — Now Available in the UAE

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Below, explore six key research-supported benefits of VIP, grounded in extensive pharmacological, preclinical, and clinical literature.

1. Potent Systemic Anti-Inflammatory and Immunomodulatory Activity
VIP is considered to be one of the body’s strongest natural anti-inflammatory agents. VIP has a direct action on NF-kappa B (NF-kappaB) in macrophage and other immune cells that results in a marked reduction in the production of inflammatory cytokine; specifically TNF-alpha, IL-6, IL-12, and IL-1 beta, while simultaneously increasing the expression of anabolic anti-inflammatory mediator and the induction of regulatory T cell (FoxP3+) differentiation. Delgado et al. and numerous others have reviewed the effects of VIP in the treatment of models of Rheumatoid Arthritis, Crohns Disease, Multiple Sclerosis and many other autoimmune diseases. By virtue of its ability to induce a shift from inflammation to tolerance with out generalized suppression of immunity, VIP will likely prove to be a valuable tool for investigators studying chronic inflammation and autoimmunity.

2. Pulmonary Vasodilation and Cardiopulmonary Protection
VIP is a very strong pulmonary vasodilator, which causes the pulmonary vascular pressure to be lower, decreases the right ventricles workload (right ventricular afterload), improves overall cardiac function and increases oxygen in blood. The clinical trials performed on patients suffering from Primary Pulmonary Hypertension, show a marked improvement in the cardiovascular system of those receiving VIP compared to those who received placebo. The study by Petkov et al., showed that in patients with low baseline levels of Endogenous VIP, administration of exogenously produced VIP resulted in a greater reduction in mean PAP (pulmonary artery pressure) than was seen in patients with normal or higher endogenous VIP levels; also saw an increase in CI (cardiac index), and an improved functional ability of the patient during exercise.

3. Gastrointestinal Motility, Secretion, and Mucosal Protection
VIP in the GI tract is associated with relaxation of smooth muscle, stimulation of both water and electrolytes secretion, regulation of motility, and also has significant protection of the intestinal epithelial layer. Additionally, VIP will inhibit acid production in the stomach while increasing bicarbonate secretion from the pancreas. Said’s original reviews identified VIP as an important regulator of normal gastrointestinal function (GI homeostasis). Therefore, due to its protective functions against inflammation and damage caused by inflammatory responses, it is a prime candidate for therapeutic use in treating conditions such as Inflammatory Bowel Disease (IBD), Leaky Gut Syndrome, Irritable Bowel Syndrome (IBS) and other studies related to the “gut-brain” connection.

4. Neuroprotective, Neurotrophic, and Cognitive Support
VIP is a neuropeptide which promotes neuronal survival, stimulates the release of astrocyte derived neurotrophic factor(s), facilitates new neurons (neurogenesis) and protects against excitotoxicity as well as oxidative stress. Through stimulation of VPAC receptors and activation of cAMP mediated signaling, it has been demonstrated that VIP can enhance the differentiation of stem cells into mature neural populations and their resilience in animal models of Alzheimer’s disease, Parkinson’s disease and traumatic brain injury, in addition to this, Waschek et al. have detailed many of the pathways through which VIP acts in order to facilitate neuroprotection within the context of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, acute damage from stroke or traumatic brain injury as well as chronic inflammatory conditions associated with neurodegeneration. In addition to providing neuroprotection, VIP also modulates the body’s circadian rhythms and provides some level of emotional support by acting on the same receptors found in other areas of the central nervous system.

5. Induction of Immune Tolerance and Autoimmune Modulation
VIP generates an environment that allows for tolerance and therefore has an effect on both generating tolerogenic dendritic cells and increasing regulatory T-cells; thus creating an atmosphere where the body’s immune response is educated to accept its own tissues as ‘self’, and to decrease auto-reaction. As such, this mechanism offers significant advantages in treating animal models of transplant rejection (and other transplant-related issues), type 1 diabetes, and other autoimmune diseases. Gonzalez-Rey et al., demonstrated that experimental autoimmune disease could be reversed by using VIP, based upon tolerance induction mechanisms; providing scientists with new tools to investigate how immune homeostasis can be achieved and restored.

6. Broader Systemic Homeostasis, Anti-Fibrotic, and Tissue Repair Effects
The primary benefits of VIP are related to core functions; however, it is also known for other important characteristics such as the inhibition of fibrosis; support of endothelial function; regulation of vascular permeability and facilitation of the healing process of tissues from various organ systems; and involvement with homeostasis (regulation) of circadian rhythmic patterns, stress responses and metabolism via VIP’s many forms of signaling.

Why Choose Our VIP Injector Pen?

Our VIP is manufactured under rigid pharmaceutical grade quality control and is subject to third party analysis of each of the following; purity, potency, identity, sterility and stability. Each lot has been verified to yield uniform results in sensitive neuroimmune, cardiopulmonary and inflammatory experiments.

By being delivered through our pre-filled injector pen (with no need to reconstitute) we have eliminated the issues that can arise with this type of product, provide precise subcutaneous dosing, minimize waste and ensure long term storage stability. The delivery mechanism will be beneficial to researchers who are utilizing a structured and constant experimental design when studying a specific pathway.

As a culmination of many years of scientific advancements in peptide development, VIP is able to uniquely interface all aspects of physiology including the nervous system, immune system, cardiovascular system and endocrine system as one system providing researchers an unparalleled opportunity to study multiple systems and potentially identify new therapeutic targets.

Consultation with a licensed healthcare professional, your Institutional Review Board or Research Ethics Committee should occur prior to initiating any experiment. These comments are made based upon scientific literature. The intent of these comments are for informational purposes only, to educate and provide information for use in the laboratory. Please do not attempt to self-diagnose or treat any medical condition(s).

Important Note: This product is intended strictly for research and laboratory use only. It is not for personal consumption, human or animal therapeutic use, or any clinical application. Please consult and fully comply with all local regulations in the UAE before purchasing or handling.