THYMOGEN INJECTOR PEN 3ML

Thymogen (Glu-Trp / EW): The Clinically Validated Thymic Dipeptide Immunomodulator for Immune Restoration, T-Cell Optimization, and Resilience — Now Available in the UAE

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“Beginning with the development of a synthetic dipeptide called Glu-Trp (L-glutamic acid-L-tryptophan), or glutamyl tryptophan and also referred to as EW; Thymogen is a very specific type of immunomodulatory bioregulator. It was found to be one of the most potent fractions derived from natural thymic extracts (known as Thymalin) using reversed phase HPLC. It was then produced for use in medicine. The structure of this small molecule is able to mimic some of the same signals that are sent by the thymus. As a result, Thymogen can enhance various aspects of the body’s ability to fight infection by activating cells such as T-cells, which play a major role in the body’s response to foreign pathogens.

As of now, Thymogen is registered as a pharmaceutical product in Russia (e.g. registration numbers include P N002408/01). In addition, due to its long history of use in humans, dating back to the 1990’s when it was first approved for use as a pharmaceutical agent, Thymogen is considered to have one of the strongest bases of evidence supporting its efficacy. Clinical studies have been conducted on Thymogen to demonstrate its effectiveness in patients suffering from impaired immune function. Additionally, studies have demonstrated Thymogen to be effective in patients recovering from chemotherapy/radiotherapy, those who have suffered from infectious diseases and those experiencing age-related declines in their immune systems.

Unlike other agents used to stimulate or suppress the immune system, Thymogen serves as a physiological regulator by enhancing the maturation/differentiation of T-cells, restoring the CD4/CD8 ratio, optimizing cytokines and enhancing NK cell activity all while providing an enhanced state of immune competency.

Through several different methods of action, Thymogen modulates the intracellular cAMP/cGMP ratio, activates protein kinases, increases transmembrane Ca²⁺ exchanges across lymphocyte membranes and targets genes involved in the thymic-like signaling pathways even if the individual does not possess a functioning thymus. Due to these properties and modes of action, researchers view Thymogen as a superior tool for exploring issues related to aging of the immune system (immunosenescence); recovery after chemotherapy/radiotherapy; chronic infections; autoimmune disorders characterized by disruptions in immune homeostasis; responses to vaccines; and overall restoration of the integrated immune system.

In order to provide our customers with an ideal method for delivering the highly purified (>99%), pharmaceutical grade, 3mL solution of Thymogen peptide via subcutaneous injection, we offer a convenient ready-to-use injector pen.

1. Acceleration of T-Cell Differentiation and Maturation
Thymogen is an excellent regulator of the Th1/Th2 cytokine balance. The balance is restored through normalized levels of the important mediators such as IL-2, IFN-γ, IL-4, etc. It prevents both hypo-immune states (immunodeficiency) and hyper-immune dysregulations (autoimmune tendency), by providing a balanced response instead of an over-response. Research published in immunological journals provide evidence that it restores the physiological cytokine ratios that support immune homeostasis and reduces pathological inflammation without compromising the body’s defensive capability.

2. Modulation of Cytokine Balance and Immune Homeostasis
Thymogen’s effects on the Th1/Th2 cytokine balance affect the number of key cytokines that are produced including IL-2, IFN-gamma, IL-4 as well as other cytokines. Thus, it may reverse either the hypoinmunne status (absence of proper immune response; or immunodeficiency); or the hypersensitivity dysregulation (inappropriate over active immune response; or autoimmunity). In addition, there exists peer reviewed literature from immunologists illustrating thymogens’ ability to potentially provide restoration of the normal cytokine ratios and stimulate immune function with less than the typical amount of inflammatory responses.

3. Accelerated Immune Recovery Following Infections
Thymogen is very effective at promoting an accelerated post-infection reconstitution of the immune system in response to challenges by bacteria, viruses, or parasites. Thymogen rapidly supports the return of lymphocytes, stimulates neutrophilic phagocytosis (the ingestion and destruction of pathogens), and decreases the frequency of subsequent infections caused by opportunistic pathogens in immunocompromised individuals.
Hospitalized cohorts’ clinical information indicate that Thymogen’s use results in quicker return to normal immune function values; and better clinical outcome; thereby providing evidence to researchers investigating recovery from infectious diseases, septic shock, and post-viral syndrome.

4. Support for Hematopoietic Recovery During Radiation and Chemotherapy
Thymogen is an adjunct studied in oncologic environments to support the hematopoetic system’s recovery from myelosuppression. The compound helps with lymphocytes and granulocytes’ (i.e., white blood cells) replenishment; thus, maintaining or supporting patients’ total white cell count levels and increasing time frames between subsequent chemotherapy regimens.

5. Reversal of Immunosenescence and Restoration of Thymic Function
Thymogen is a direct counter to age-associated thymic involution — the process by which the thymus shrinks over time as part of the aging process that results in immunosenescence. The Thymogen restores functionally competent T-cells to elderly subjects through replacement or supplementation of diminished levels of thymic hormones, thereby restoring both quantity (output) and quality (diversity and functionality) of T-cells produced by the thymus. Research with older individuals has demonstrated an increase in vaccination efficacy, decrease in incidence of seasonal and opportunistic infections and improvements in immune surveillance in general; these benefits demonstrate that Thymogen can be used in longevity/anti-aging/senior health studies.

Why Choose Our Thymogen Injector Pen?

Thymogen has been produced by trusted suppliers that have long-standing history associated with pharmaceutical grade products. The final product is tested using strict quality control processes to ensure it meets the required standards for purity, potency, identity, sterility and stability. Each new lot of Thymogen is certified to allow researchers to reliably obtain high quality results when conducting their immunology studies.
The injector pen format of our product also eliminates the difficulties typically associated with administering peptides subcutaneously (under the skin) such as having an adequate dose delivered and maintaining the correct stability of the peptides. The user-friendliness of this delivery system makes it suitable for both short term intense study cycles and longer cycles where researchers may be looking at chronic effects.
In addition, due to its registration status as a drug in several countries and a strong base of biological knowledge accumulated over many years through Dr. Khavinson’s bioregulator work, there is a substantial body of evidence available supporting the use of Thymogen as one of the most robust peptide-based immunomodulators currently available. Regardless if you are studying aspects of T cell biology, immune reconstitution in patients undergoing chemotherapy, cancer supportive care, vaccines or simply how to maintain health during the natural aging process; Thymogen will provide you with a reliable and physiologic method of delivering your desired outcome.
It is always necessary to consult a qualified physician, research ethics committee, or Institutional Review Board prior to commencing any clinical trial. All references contained within these documents are based upon existing scientific literature and are presented solely for informational and educational purposes.

Important Note: This product is intended strictly for research and laboratory use only. It is not for personal consumption, human or animal therapeutic use, or any clinical application. Please consult and fully comply with all local regulations in the UAE before purchasing or handling.