SS-31 (ELAMIPRETIDE) INJECTOR PEN 3ML

SS-31 (Elamipretide): The Mitochondria-Targeted Tetrapeptide for Cellular Energy Restoration, Organ Protection, and Mitochondrial Medicine — Now Available in the UAE

The SS-31 peptide, which is a synthetic tetrapeptide (D-Arg-2′,6′-dimethyl-Tyr-Lys-Phe-NH₂), was developed by Dr. Peter W. Schiller & Dr. Hazel Szeto. SS-31 is one of the most groundbreaking peptides in the field of mitochondrial medicine. Antioxidants are generally dispersed throughout cells but have poor ability to be taken up into mitochondria. By design, SS-31 is able to accumulate in the inner mitochondrial membrane at >1000 fold levels due to its strong affinity to bind cardiolipin, which is the signature phospholipid that forms the ETC super complexes.

SS-31 binds to cardiolipin and thereby helps to stabilize cytochrome C, optimize electron transfer efficiency, decrease electron leak and ROS production, inhibit cardiolipin oxidation and mPTP pore opening. All of these mechanisms will help to restore oxidative phosphorylation, improve ATP production and protect mitochondria from damage due to oxidative stress, ischemia, age and excess energy burden. As of now, SS-31 is being investigated in phase 2 and phase 3 clinical trials for Barth Syndrome, HFpEF Heart Failure with Preserved Ejection Fraction, Primary Mitochondrial Myopathy and other mitochondrial diseases; thus SS-31 is among the most advanced mitochondria targeted compound(s) currently being investigated.

This premium SS-31 injector pen is filled with 3 ml of a peptide solution that is prepared according to strict GMP guidelines and is greater than 99% pure. The injector pen is designed to provide an easy method of subcutaneously administering an exact amount of SS-31 to ensure excellent bioavailability to the mitochondria and to make use of advanced mitochondrial, cardiovascular, neurological and longevity research study designs easier.

Below, explore six key research-supported potential benefits of SS-31, grounded in peer-reviewed pharmacological, preclinical, and translational studies.

1. Restoration of Mitochondrial Bioenergetics and ATP Production
Mitochondrial respiration is enhanced through direct stabilization of ETC super complexes as well as improved coupling efficiency with less proton leakage. As a result, there is an increase in ATP synthesis with a resultant restoration of cellular energy production in older ischemic or metabolically challenged tissues. In addition to enhancing cellular ATP production, Birk et al. (Journal of the American Society of Nephrology), have shown that SS-31 has re-energized ischemic mitochondria; improved ischemia induced ATP recovery rates; and decreased oxidative stress in renal tubular cells.

2. Cardioprotection and Reversal of Age-Related Cardiac Dysfunction
SS-31 compound is a first-in-class therapeutic agent for preserving the structural and functional integrity of mitochondria in cardiac tissue, thereby preventing loss of mitochondrial cristae structure, oxidation of cardiolipin and ultimately reducing the final area of myocardial damage post MI. Further, it has been shown to prevent the energetic deficits associated with both aging and heart failure progression. In an experiment conducted by Dai et al. (Journal of the American Heart Association), administration of SS-31 for eight weeks restored cardiac function in aged mice to near youthful values compared to young mice. Specifically, the results demonstrated that SS-31 was able to reverse age-associated left ventricular hypertrophy, diastolic dysfunction as well as age-induced alterations in mitochondrial ultrastructure.

3. Renal Protection Against Ischemia-Reperfusion and Fibrotic Injury
The protective effects of SS-31 on the renal tubules have been demonstrated as a method for protecting mitochondrial function from injury due to acute ischemia. The use of SS-31 has also shown to protect against the progression of chronic kidney disease through reducing or eliminating fibrotic changes and promoting ATP production with less oxidative damage than would occur without treatment. Szeto et al. demonstrated long-term preservation of tubular structure after ischemia/reperfusion, unilateral ureteral obstruction (UUO) injury and subsequent fibrosis when utilizing SS-31.

4. Improvement of Skeletal Muscle Function and Exercise Capacity
The improvement of mitochondrial energetics in skeletal muscles has been demonstrated to increase endurance, reduce fatigue and improve physical performance through reduction in fatigability as well as a decrease in oxidative stress and muscle atrophy due to an enhancement in the ability of mitochondria to produce energy in muscle fibers.

5. Neuroprotection and Potential Cognitive Support
SS-31 is able to penetrate the blood-brain barrier where it provides protection for the neurons’ mitochondria against oxidative stress, amyloid beta induced damage, and neuro-inflammation. SS-31 has also been shown to support the synapse’s function as well as potentially delay or possibly prevent the progression of neuro-degeneration through its protective effects on mitochondrial function within the brain. Studies conducted using the journal “Neurobiology of Aging” and other animal models have indicated that SS-31 can help improve impaired spatial memory in transgenic Alzheimer’s disease mice. In addition, studies indicate that SS-31 offers some level of neuro-protection in these same animals.

6. Broad Cytoprotection, Anti-Inflammatory Effects, and Longevity Potential
Mitochondrial activation through reduction of ROS and optimization of the signal transduction pathway results in protective and anti-inflammatory effects on cells throughout an organism. Additionally, SS-31 can act on several biochemical pathways associated with inflammaging and support cellular resilience when exposed to chronic stresses. The broad range of mechanisms that SS-31 acts upon position it at the forefront of potential therapeutic options to investigate mitochondrial disorders affecting single or multiple organs, metabolic syndromes, aging, and the extension of healthy lifespan.

Why Choose Our SS-31 Injector Pen?

All batches of our SS-31 are produced to exacting pharmaceutical quality standards and tested by independent third party laboratories for purity, potency, identification, sterility and stability. Each batch has been evaluated to provide consistent high quality data in sensitive studies of mitochondrial function and cytoprotective effects.

Our engineered injector pen format was designed to eliminate reconstitution problems; to ensure accurate subcutaneous dosage; to minimize waste; and to provide the best possible storage stability. The delivery system is suitable for laboratory researchers as well as for researchers who require reliable administration of drug in a defined cyclic regimen with respect to time.

SS-31 (Elamipretide), represents one of the most promising agents for application in mitochondrial medicine. With its mechanism of action targeting cardiolipin, it offers researchers an exceptionally potent, and highly advanced clinical agent for the study of mitochondrial bioenergetic processes, organ protective mechanisms, ischemia/reperfusion damage, aging related loss of function and innovative therapeutic approaches that may help restore cellular energy and function.

Before initiating any experimental protocol you should always obtain advice from a qualified medical professional, your local research ethics committee or institutional review board. These statements have been made in accordance with the scientific literature and are provided solely for informational and educational purposes. These statements are not to be used for diagnosis, treatment, prevention or cure of any disease.

Important Note: This product is intended strictly for research and laboratory use only. It is not for personal consumption, human or animal therapeutic use, or any clinical application. Please consult and fully comply with all local regulations in the UAE before purchasing or handling.