PANCREAGEN INJECTOR PEN 3ML

Pancreagen (Lys-Glu-Asp-Trp / KEDW): The Dual Exocrine-Endocrine Pancreatic Bioregulator for Metabolic Health, Insulin Sensitivity, and Digestive Restoration — Now Available in the UAE

The Tetra Peptide KEDW (lysine-glutamic acid-aspartic acid-tryptophan; lys-glu-asp-trp = pancreatein), is a Bioregulatory, developed specifically by Prof. V. A. Khavinson, as part of the group he directed. The short-chain tetrapeptide was synthesized based on an analysis of amino acids from complex peptides found naturally in the pancreas. It has specific tropisms for the two compartments of the pancreas i.e., exocrine (or acinar cells), where digestive enzymes are produced, and endocrine (or islet cells), which produces hormones that regulate metabolism. It is intended to counteract the multi-factorial decrease in pancreatic function that occurs due to aging, overloading of the body’s metabolism, long-standing inflammation, and/or poor diet.

Unlike traditional metabolic intervention methods, such as those targeting insulin signaling/blood sugar levels alone, Pancreagen is used at an epigenetic level. It enters into the nuclear membrane of pancreatic cells and interacts directly with DNA/chromatin to normalize genetic transcription patterns involved in hormone production/digestive enzyme formation/anti-apoptosis/tissue repair. As such, it has a dual effect: stimulating beta-cells to produce insulin/generating glucagon from alpha-cells/enhancing exocrine function to restore the normal functioning of the entire gland.

Pancreagen provides researchers with a valuable tool for studying: the pathophysiology of Type II Diabetes/Metabolic Syndrome/Pancreatic Exocrine Insufficiency/Congestive Pancreatitis/Aging-induced Beta Cell Dysfunction/Glucolipotoxicity/Holistic Regenerative Studies of Metabolically-Degraded/Dysfunctional Pancreata. Additionally, its unique ability to protect islets from toxicity and improve exocrine function make it an ideal agent for investigating regenerative therapies aimed at improving overall pancreatic function.

The 3 ml injector pens contain a highly pure (>99%) peptide solution that has been subjected to strict quality control measures. The pens are self-contained and provide subcutaneous injections, ensuring that the correct amount of peptide is administered into the animal and maximizing bioavailability within the pancreas. The pens also maximize researcher convenience when using them for either acute studies lasting weeks/months or prolonged cyclical treatment programs and ensure stable conditions for the peptides throughout their shelf life.

Below, explore six key research-supported potential benefits of Pancreagen, grounded in mechanistic preclinical data and Khavinson bioregulator science.

1. Enhancement of Beta-Cell Function and Glucose-Stimulated Insulin Secretion
Pancreagen is able to normalize levels of insulin gene (INS) expression as well as support several elements that are part of the glucose stimulated insulin secretion (GSIS) pathway in beta-cells. It also reverses impaired responses to glucose stimulation (functional), increases overall insulin secretory capacity, and preserves beta-cell mass when used on models of islets from older animals or those under metabolic stress. These aspects are of particular interest to researchers studying early stage Type 2 Diabetes, Beta-Cell Exhaustion, and preservation of natural insulin production through mechanisms that do not require exogenously administered hormones.

2. Restoration of Exocrine Pancreatic Enzyme Production
The pancreas is made up of endocrine cells that produce hormones and acinar cells that secrete digestive juices. These digestive juices include amylase, lipase, trypsinogen, and other proteases that help with protein digestion. When we eat, our stomach secretes hydrochloric acid to break down food into a liquid. Our liver produces bile salts from cholesterol to emulsify fats. Once these liquids enter the small intestine they are mixed with the pancreatic secretions as well as secretin which stimulates the pancreas to release bicarbonate. Bicarbonate then helps neutralize acids so digestive enzymes can work properly. Acinar cell function declines in aging and it has been shown that the addition of Pancreagen will restore enzymatic activity through reactive gene expression resulting in normal pancreatic secretions; thereby enhancing the ability of the body to digest proteins, carbohydrates and fats leading to enhanced nutrient uptake.

3. Potent Anti-Inflammatory and Tissue-Protective Effects
Pancreagen acts to diminish pro-inflammatory signals in the pancreatic tissue thereby decreasing mediators that are involved with inflammation, which leads to the development of edema (swelling), leukocyte infiltration (inflammation) and fibrosis, in addition, it will help preserve the structure of both the acinar and islet cells in the event of an inflammatory challenge either acute or chronic. Experimental pancreatitis studies have demonstrated significant reduction in tissue damage from experimental pancreatitis and quicker resolution of inflammation, thus maintaining histological integrity; this positions it as a potential tool in recovering from pancreatitis and conducting research into chronic inflammatory pancreatic disease.

4. Cellular Protection Against Glucotoxicity and Lipotoxicity
The product protects beta cells from death caused by either a high glucose diet or a high fat diet; it also helps protect against three major causes of chronic progressive beta-cell failure — namely anti-apoptotic gene expression, mitochondrial function, and ER stress. The effects were shown in vitro (in a test tube) with marked improvements of beta-cell viability and secretory ability even when exposed to hyperglycemia over time.

5. Balanced Regulation of Insulin and Glucagon for Metabolic Homeostasis
Pancreagen supports physiological counter-regulation of blood glucose by regulating beta- and alpha-cell gene expression at the same time. Therefore, it can help to maintain a stable balance between blood glucose levels that are too high (hyperglycemia) and those that are too low (hypoglycemia), as well as improve an individual’s ability to handle blood sugar.

6. Support for Pancreatic Regeneration and Anti-Aging Effects
Pancreagen has been shown to counteract some of the effects of biological aging in the pancreas by reversing the epigenetic silencing that occurs as a result of aging. In doing so, it stimulates cell growth and renewal; inhibits senescent cells; and maintains both the exocrine and endocrine components of the pancreas throughout life. The results of longitudinal animal models show maintained pancreatic function, improved histology and delayed onset of aging related deterioration of the pancreas making it an attractive choice for all types of studies on longevity/geroprotection/metabolic health prevention.

Why Choose Our Pancreagen Injector Pen?

Our Pancreagen is made by established producers that have been working with Dr. Khavinson in the area of peptide synthesis. It has undergone extensive quality assurance testing by an independent third party for purity, potency, identify, sterility and stability. Each batch is tested to insure it meets our very high expectations for consistency in laboratory and clinical metabolic and pancreatic studies.

The design of our precision engineered injector pens allows for easy subcutaneous injection, precise dose control, minimizes waste and is stable during long term storage. The delivery system is well-suited for use in daily or cyclic application protocols in laboratory, investigative and clinical environments.

Pancreagen represents the current state-of-the-art in tissue-specific bioregulation. With its unique dual targeting of both endocrine and exocrine functions of the pancreas, Pancreagen presents investigators with a sophisticated tool to study pancreatic regeneration, metabolic restoration and other systemic methods for addressing diabetes and gastrointestinal health issues.

Please consult with your qualified healthcare professional and/or obtain approval from a local Research Ethics Committee (RECs) and/or Institutional Review Board (IRB), as applicable, prior to initiating any new protocol. All statements presented above are derived from published scientific articles and were developed for informational/educational purposes only. None of these statements should be construed to represent a diagnosis, treatment, cure or prevention of any disease.

Important Note: This product is intended strictly for research and laboratory use only. It is not for personal consumption, human or animal therapeutic use, or any clinical application. Please consult and fully comply with all local regulations in the UAE before purchasing or handling.