OVAGEN INJECTOR PEN 3ML

Ovagen (Lys-Glu-Asp / KED): The Dual-Target Gut-Liver Axis Bioregulator for Hepatic, Gastrointestinal, and Metabolic Restoration — Now Available in the UAE

Ovagen, also referred to as the tripeptide Lys-Glu-Asp (KED), is an advanced, highly targeted, Khavinson-class short-chain bioregulator designed by Dr. Vladimir Khavinson and his team at the St. Petersburg Institute of Bioregulation and Gerontology. Based upon the amino acid sequences from the hepatic and gastrointestinal tissues, Ovagen is a small peptide that has strong dual-tropism toward liver hepatocytes and gastrointestinal epithelial cells. It acts as a “master” regulatory protein of the gut/liver axis — the bidirectional communication pathway between the intestinal barrier’s functional status, microbial metabolite production and absorption, biliary acid recirculation, and hepatic metabolic activity.

The primary mechanism of action of Ovagen is at the epigenetic level. Ovagen acts upon chromatin within the target cell to normalize gene expression; it restores functioning of proliferation pathways (i.e. Ki-67), detoxification enzyme systems, tight junctions, anti-apoptotic signals, and tissue repair pathways that are normally turned off due to aging, inflammation, toxin exposure, and/or metabolic stress. By acting through these pathways in concert, Ovagen will help restore normal mucosal barrier function in the intestine while improving functioning of hepatocytes, biliary fluid production and first pass metabolism in the liver.

Due to its unique profile, Ovagen represents an ideal research compound for studying intestinal permeability (“leaky gut”), chronic liver diseases such as cirrhosis, metabolic syndrome including NAFLD, post-hepatitic recovery, toxin induced liver injury, dyspeptic disorders, malabsorptive states and other components of the gut/liver/microbial axis. Additionally, as it can provide simultaneous enhancement of digestive efficiency and hepatic detoxification capabilities, Ovagen is positioned at the leading edge of advances in integrative gastroenterology/hepatology/gero-proteomics/metabolic medicine.

Our premium OVAGEN Injector Pen contains a precisely formulated 3mL solution of high purity (>99%) peptide produced using the highest standards of quality control. Our sub-cutaneously administered, easy-to-use delivery system provides consistent bioavailability of our peptides to both gut and liver tissues and offers significant ease-of-use when compared to traditional intravenous or oral administration methods used in advanced metabolic/digestive/hepatic studies. The pen format allows flexibility with dosing regimens (i.e. daily/cyclic etc.) and maintains peptide stability.

Below, explore six key research-supported potential benefits of Ovagen, grounded in mechanistic preclinical data, cellular studies, and Khavinson bioregulator science.

1. Reinforcement of GI Mucosal Barrier Integrity and Repair
Ovagen enhances the turnover of cells in the epithelium layer and increases expression of the tight junction proteins; specifically zonula occludens and occludin that are found in the mucous membranes of the intestines. As a result, Ovagen creates an enhanced structural barrier function which will reduce the degree to which substances can cross through paracellular routes into systemic circulation. This results in accelerated repair of damage to the mucous membrane due to inflammation, infection, toxic insult and aging. Decreased intestinal permeability has been observed and rapid mucosal recovery have been demonstrated in preclinical studies suggesting that Ovagen is of particular interest for future research on leaky gut syndrome, IBS, inflammatory bowel disease and malabsorption.

2. Normalization of Hepatic Function and Detoxification Capacity
Ovagen is a compound that is used to support the expression of genes by liver cells (hepatocytes) as it relates to their function in producing proteins such as albumin; in metabolizing drugs using the cytochrome P450 family of enzymes; in preventing oxidative damage through its antioxidant functions; and in producing bile acids. As a result, Ovagen can help support the liver’s ability to process toxins quickly and efficiently during “first pass” metabolism which occurs when substances are introduced into the body via oral ingestion. Furthermore, Ovagen has been shown to provide protection from oxidative and metabolic stress.

Several studies have demonstrated the beneficial effects of Ovagen on the function of aged or substance exposed livers. In these studies, researchers reported improvements in various aspects of liver health including improved liver enzyme profiles; an increase in detoxifying capabilities; and improved metabolic processes. These findings suggest that Ovagen would be useful for animal model-based research related to non-alcoholic fatty liver disease (NAFLD), drug-induced liver injury, and other conditions associated with aging and decreased liver function.

3. Regulation of Digestive Enzyme Secretion and Nutrient Absorption
Ovagen is able to normalize the gene expression of all three major cell types involved in the digestive process (gastric chief cells; parietal cells; and pancreatic acinar cells). Therefore, it enables proper secretion of digestive enzymes including pepsinogen and hydrochloric acid. Improved protein digestion, improved nutritional absorption, and ultimately enhanced overall digestive efficiency are the outcomes of this normalization.

4. Potent Anti-Inflammatory Effects Across the Gut-Liver Axis
Ovagen reduces pro-inflammatory cytokines within the intestines (intestinal lamina propria) and liver (hepatic tissue), thus supporting a state of immune balance, as well as reducing the levels of low-grade chronic inflammation in these tissues. In addition, it can help to reduce stressors that promote an imbalance of bacteria (dysbiosis) and inflammation from the gut into the bloodstream and subsequently the liver. Thus, this balanced form of modulating the inflammatory response is also conducive to a resolution of inflammation while avoiding a generalized suppression of the immune system, and therefore, would be useful in research studies involving disorders of the gut-liver axis, including autoimmune hepatitis, and metabolic inflammation.

5. Support for Post-Hepatitis, Toxic, and Regenerative Recovery
Ovagen is a compound that has shown to protect against fibrosis during liver damage caused by viruses or chemicals through stimulating the expression of liver regenerative genes. It helps accelerate the normalizing of liver enzyme levels and structural improvements with concurrent gut healing and restoration. The beneficial effects of Ovagen include its potential use in research projects such as studying hepatitis recovery, protecting from radiation/chemotherapy induced damage, study of the impact of toxins from environment on liver health and post-acute treatment of liver damage.

6. Overall Metabolic Homeostasis and Anti-Aging Protection
By linking gut barrier function to hepatic metabolism, Ovagen is able to help modulate glucose and lipid management by reducing oxidative damage and helping to mitigate the cellular senescent markers (e.g. p16, p21, p53), while promoting longevity associated pathways (e.g. SIRT6). Ovagen has been demonstrated in pre-clinical studies as a treatment option for age-related changes across the gut-liver axis through longitudinal analysis of preserved organ function; improved metabolic health metrics; and delay of aging related effects in treated models. The results demonstrate that it may be beneficial in both longevity research and prevention of metabolic disease.

Why Choose Our Ovagen Injector Pen?

Our Ovagen product is manufactured by well-established companies with a long history of producing peptides using the method developed by Dr. Khavinson. Each lot of our product has been tested under contract through independent laboratories for purity, activity, identity, sterility and shelf life. In addition, each batch of Ovagen has been examined to ensure that it meets all requirements for reproducibility in sensitive research involving liver, intestine and metabolism.

Ovagen comes in a precise engineered injector pen which allows for easy subcutaneous administration. The use of this injector pen also provides an accurate means of measuring dosage levels while minimizing wasted material as well as providing good storage stability. The design of the injector pen makes it suitable for implementing consistent daily or cyclic treatment regimens in clinical or investigative studies.

Ovagen demonstrates the precision and integration of Khavinson’s bioregulatory sciences. By targeting the relationship between the gut and the liver (the gut-liver axis), Ovagen provides scientists with a highly sophisticated epigenetic agent used to investigate barrier function, detoxification, digestive efficiency and overall systemic metabolic health.

Important Note: This product is intended strictly for research and laboratory use only. It is not for personal consumption, human or animal therapeutic use, or any clinical application. Please consult and fully comply with all local regulations in the UAE before purchasing or handling.