HUMANIN INJECTOR PEN 3ML

Humanin: The Mitochondrial-Derived Peptide for Cytoprotection, Neuroprotection, and Longevity Research — Now Available in the UAE

The first study on humanin was conducted by Hashimoto et al. in 2001. They were searching for neuroprotection against neurotoxicity due to Alzheimer’s disease when they identified this new MDP. It is a 24 amino acid long peptide produced from mt-rnr2; which codes for the 16s rRNA gene. Hashimoto et al.’s findings have shown that mitochondria can create peptides that help cells survive, metabolize and react to stress. Researchers believe that humanin is an important tool in investigating how we grow older, neurodegenerative diseases, metabolic disorders and heart health.

Humanin creates protective effects against cells in several ways: by binding and neutralizing igfbp-3 thereby creating more igf-1 available to be used by the body; activating stat3 and erk1/2 in cells to promote survival by using the ciliary neurotrophic factor receptor complex; and by preventing bax from moving into the mitocondrial outer membrane to induce apoptosis (cell death).

This makes humanin useful in protecting cells exposed to oxidative stress, amyloid toxin, ischemia, metabolic disorder or the process of growing old. The amount of humanin found circulating in the blood stream and located in tissues decreases with age. Studies on human centenarians show higher amounts of endogenously generated humanin are related to longer life expectancy.

Therefore, humanin remains an investigational compound that is receiving much attention scientifically, as possible link between mitochondrial activity, systemic resiliency and healthy aging.

Below, explore six key research-supported potential benefits of Humanin, grounded in peer-reviewed pharmacological, cellular, and in vivo studies.

1. Neuroprotection Against Alzheimer’s Disease and Neurodegenerative Processes
The potent inhibition of amyloid beta induced cell loss to humanin has been shown to reduce phosphorylated tau levels. This reduction is a direct result of the protection of the hippocampus and cortex by reducing oxidative damage and excitotoxicity in cells. Additionally, activation of STAT3 signals and suppression of pro-apoptotic signaling indicate a wide array of neuroprotection for Humanin. Humanin was initially identified by Hashimoto et al. (PNAS, 2001) as the first mitochondria derived neuroprotective factor when it protected cortical neurons from amyloid beta induced cytotoxicity using an in vitro system as well as with an in vivo model.

2. Improvement of Metabolic Regulation and Insulin Sensitivity
Humanin (HUM) is a peptide that has been shown to have several beneficial effects on metabolism; these include increasing peripheral insulin sensitivity by decreasing hepatic glucose production, thus improving overall glucose homeostasis. HUM has been found to reduce visceral fat accumulation and slow down or counteract many of the age-associated changes to an organism’s metabolic profile. Further evidence supporting the role of HUM as an important mediator of metabolic health comes from studies demonstrating circulating HUM levels are inversely related to indicators of Metabolic Syndrome in humans. In addition to the positive impact of Humanin administration on the metabolic status of older animals demonstrated by Muzumdar et al., they also found that it enhanced glucose uptake into cells and increased the body’s ability to utilize glucose for energy.

3. Cardiovascular Protection and Ischemia-Reperfusion Resilience
Humanin is a protein known to protect heart muscle cells from injury due to lack of oxygen (ischemia) followed by an increase in blood flow (re-perfusion), diminishes the area of damaged heart muscle, maintains or preserves the ability of the left side of the heart to pump effectively and decreases oxidative damage to heart muscle. Humanin also has been shown to block apoptosis (programmed cell death) in mitochondria as well as prevent oxidative damage caused by acute cardiac stress. According to Thummasorn et al., when rat models were given a dose of Humanin prior to a myocardial infarction, they had approximately 50% less damaged area of their hearts than those that did not receive Humanin. The rats who received Humanin had better ejection fractions and decreased levels of oxidative stress markers than those without Humanin treatment.

4. Direct Anti-Apoptotic Activity via BAX Inhibition
Humanin attaches to BAX as an inhibitor to prevent the change of shape that is necessary for the oligomerization and translocation of BAX to the mitochondria outer membrane which inhibits the activation of programmed cell death through multiple pathways in various cell types such as neurons, cardiomyocytes and pancreatic beta cells. In their Nature paper (2003), Guo et al. found that Humanin was able to structurally bind to BAX in order to block mitochondrial outer membrane permeability – a key point at which programmed cell death occurs.

5. Promotion of Longevity and Systemic Stress Resilience
Higher circulating humanin levels are observed in centenarians and their offspring. Exogenous administration of humanin to animal models improves markers of healthspan, mitochondrial function, cognitive performance and resistance to multiple age-related stressors.
Studies by Yen et al. (aging, 2018), relatives of studies show that humanin is associated with exceptional longevity. Furthermore, they found that this peptide can prevent cognitive decline as we age while also enhancing our physiological resilience

6. Mitochondrial Function Optimization and Broader Cytoprotection
Humanin helps maintain mitochondria’s function, decreases ROS (reactive oxygen) formation, and promotes mitochondrial energy efficiency during stressful states. Therefore, it can be seen as cytoprotective in pancreatic beta cells, skeletal muscles, and endothelial cells which makes it relevant for researching multi-organ aging, and metabolic diseases.

Why Choose Our Humanin Injector Pen?

The humanin we synthesize meets the highest standards for manufacturing and undergoes extensive third party testing for purity, potency, identity, sterility, and stability. Each batch has been tested to allow for the replication of data across all sensitive areas of cytoprotection, neuroscience, metabolism, and longevity research.

The precision engineered subcutaneous delivery mechanism via the use of an injector pen eliminates the need for reconstituting humanin prior to injection; it allows for precise subcutaneous dosing (minimizing waste), and provides long-term stability when stored. This delivery method will meet the needs of both academic/clinical investigator laboratories and/or provide structure for larger scale research studies that require consistent humanin injections.

Humanin represents perhaps the most exciting area of investigation into mitochondrial derived peptide-based aging/cytoprotection science today. By virtue of its ability to interface with mitochondrial signaling systems while also interacting with systemic survival mechanisms; this peptide may serve as an important resource for those investigating the pathogenesis of neurodegenerative diseases, metabolic disorders, cardiovascular resiliency and healthy longevity.

Please always contact your primary care physician, your local Research Ethics Committee, or Institutional Review Board prior to starting any study. The information contained in these statements is based on peer reviewed articles, are provided solely for informational purposes and education. These statements should not be interpreted as diagnosis, treatment, prevention or cure for any disease.

Important Note: This product is intended strictly for research and laboratory use only. It is not for personal consumption, human or animal therapeutic use, or any clinical application. Please consult and fully comply with all local regulations in the UAE before purchasing or handling.