CORTAGEN INJECTOR PEN 3ML

Cortagen (Ala-Glu-Asp-Pro / AEDP): The Precision Cerebral Cortex Bioregulator for Neuroprotection, Cognitive Restoration, and Neuronal Regeneration — Now Available in the UAE

Cortagen, chemically referred to as Ala-Glu-Asp-Pro (AEDP), is a tetra-peptide bioregulator, which has been specifically designed by the team of Professor Vladimir Khavinson. The compound has been synthesized using targeted synthesis technology and the data obtained from an analytical study of amino acid sequences present in the complexes of peptides extracted from bovine cerebral cortex, specifically Cortexin. As one of the shorter-length peptide compounds developed by Khavinson (typically two to four amino acids), Cortagen has been engineered to be highly specific in its ability to target the cerebral cortex; this region of the brain governs all aspects of higher-order thought processes including executive functions, memory encoding and retrieval, sensory integration, motor coordination, language, decision-making, and consciousness.

Unlike other types of traditional nootropic substances that temporarily stimulate neural signaling via neurotransmitters or increase blood flow, Cortagen acts primarily at the level of epigenetics/transcription. Cortagen works by interacting with chromatin in the cortical neuron cells to open-up previously condensed DNA structures thereby stimulating the transcriptionally silenced genes that are gradually down-regulated throughout the course of normal aging due to oxidative damage, inflammation caused by neuro-inflammation, stroke/ischemia, or traumatic brain injury. These gene regulatory actions promote increased production/translation of critical neurotrophic factors (BDNF and NT-3) involved in neuronal survival and growth, along with proteins necessary for maintaining/synthesizing synaptic connections (synaptic proteins such as PSD-95, synaptophysin, and synapsin-I). Additionally, Cortagen stimulates/enhances the production of antioxidant enzymes (SOD2 and catalase) involved in combating oxidative damage and anti-apoptotic pathways while promoting the overall maturation/differentiation of neurons.

The primary mechanisms associated with the development of Cortagen, have enabled it to be used as a model substance for pre-clinical studies aimed at investigating the pathophysiology of various forms of cognitive degeneration and degenerative neurological disorders including but not limited to, age-related cognitive decline, various forms of neurodegeneration such as Parkinson’s disease, Alzheimer’s disease and Huntington’s disease, recovery from stroke/TBI injuries, peripheral nerve repair/regeneration and strategies to prevent/promote cortical atrophy. Research studies have indicated additional secondary effects related to Cortagen on immune system function and cardiac gene expression; these findings suggest a much wider applicability for Cortagen than initially hypothesized in terms of both its potential therapeutic applications in gerontology/neuroscience.

The Cortagen premium injector pen delivers an accurately measured (to 3 ml) formulation of > 99% purity peptide with all required quality controls to ensure that you are working with a stable and well-defined compound. The subcutaneous injection will be ready to use, as it is in a ready-to-administer formulation. The subcutaneous route provides the highest bioavailability possible, which results in the best efficacy. Additionally, the injectable pen has been developed to save researchers’ valuable time by minimizing the amount of time required to prepare their animals for administration. These pens can be used in either acute or chronic studies.

1. Enhancement of Cognitive Function, Learning, and Memory Consolidation
Cortagen was able to enhance learning indices and memory retention in older animal model systems. The use of gene reactivation enabled by Cortagen, also allowed for enhanced expression of markers associated with neuroplasticity which resulted in improved performance in cognitive based tasks that were related to the Morris water maze and novel object recognition tests.
Research indicated improvements in speed or latency, as well as an improvement in the amount of information consolidated from short-term to long-term memory for Cortagen treated subjects, indicating that this technology may provide researchers with new avenues for studying methods for potentially reversing (or at least mitigating) cognitive decline caused by aging and enhancing higher-order function of the cerebral cortex.

2. Neuroprotection and Accelerated Recovery in Post-Stroke and Traumatic Brain Injury Models
Cortagen displays significant neuroprotection against both ischemia and trauma in experimental systems. In addition, cortagen stimulates the activation of genes involved in the promotion of neuronal survival in those penumbra regions that are most susceptible to death following an insult such as a stroke or traumatic brain injury. Furthermore, cortagen suppresses apoptosis which is a common mechanism leading to cell death after many forms of insult and facilitates tissue repair.
Data from preclinical studies demonstrate enhanced neurological deficit scores; quicker restoration of motor functions; and enhanced nerve regeneration after peripheral nerve injury (i.e., cortagen resulted in approximately 27-40% increase in nerve growth rate and/or nerve conduction velocity compared with sham controls). Therefore, these results suggest cortagen has potential therapeutic applications in the treatment/rehabilitation of patients suffering from stroke injuries, TBI and other peripheral nerve injuries.

3. Robust Strengthening of Cortical Antioxidant Defenses and Oxidative Stress Resistance
Cortagen is shown to increase levels of the mitochondria antioxidant enzymes superoxide dismutase (SOD) 2 and catalase in the cortex; these can help to counteract reactive oxygen species, decrease lipid peroxidation, and inhibit oxidative protein damage that contribute to a decline in function of the neuron and rapid deterioration of the brain due to aging.
By maintaining redox homeostasis and protecting mitochondrial integrity during prolonged states of metabolic stress, inflammation or other forms of insult from an individual’s environment, cortagen has been found to promote long term health of cells across a range of models for oxidative stress and aging.

4. Promotion of Neuroplasticity, Dendritic Arborization, and Synaptic Density
Cortagen supports a brain’s ability to adapt structurally through increasing the number of dendritic spines that can be formed, allowing for greater plasticity at synapses as well as enhancing LTP (long term potentiation) within the brain. Electrophysiology and microscopy has shown an increase in the amount of branching found on dendrites; a significant increase in the number of spines per dendrite; and an overall increase in the expression of synaptic proteins within both treated cortical and hippocampal neurons.

5. Mitigation of Age-Related Cortical Atrophy and Neuronal Loss
Longitudinal observations in aged models show preserved cortical architecture and superior cognitive function compared to unreated controls. Additional studies indicate that it may also have benefits for immune response modulation (e.g., interleukin-2 expression), and brain resilience more broadly, therefore providing a new tool for geroprotective and multi-system studies of aging.

Why Choose Our Cortagen Injector Pen for Your Research?

Cortagen is supplied by reliable, high-quality manufacturers and tested through a multi-step third party process for quality (purity, potency), identity and sterility. All batches of Cortagen are checked against very strict standards required to guarantee reproducible results in all studies of the nervous system.

The injector pen has been engineered for precise, easy-to-use subcutaneous injection with minimum loss of product and maximum shelf life when stored. It is an excellent way to maintain consistency in administering the same amount of Cortagen every day as part of either a routine study or cyclical study design used within both laboratory and clinical settings.

Regardless of what area you are studying (cognitive restoration, neuroregeneration, epigenetic modification of age-related changes in the brain, etc.) Cortagen provides a proven, characterized compound that has its roots in over thirty years of Khavinson’s bioregulatory science. Please always check with a licensed medical professional or a member of your institution’s Research Ethics Committee/Institutional Review Board prior to beginning any new treatment regimen.

Important Note: This product is intended strictly for research and laboratory use only. It is not for personal consumption, human or animal therapeutic use, or any clinical application. Please consult and fully comply with all local regulations in the UAE before purchasing or handling.