CHONLUTEN INJECTOR PEN 3ML

Chonluten (Glu-Asp-Gly / EDG / T-34): The Dual-Target Mucosal Bioregulator for Respiratory, Gastrointestinal, and Lung-Gut Axis Renewal — Now Available in the UAE

Chonluten (the tripeptide Glu-Asp-Gly; EDG or T-34) is a highly specific Khavinson class of short chain bioregulator. As the product of Dr. Khavinson’s research, this compound was developed using synthetic processes that utilize amino acid sequences obtained directly from the mucosa of animals. The small size and unique tropic properties of this compound allow it to act specifically on both pulmonary and gastrointestinal (GI) mucous membranes. For these reasons, it can be classified as a comprehensive mucous membrane regulator.

In addition to having many characteristics similar to those of other bioregulators such as Bronchogen which have strong tropisms toward pulmonary mucous membranes, Chonluten has an additional and unique property that allows it to exert epigenetic effects on the enterocyte cells of the intestine and other cell types found within the lining of the GI tract. The mechanisms by which Chonluten exerts its regulatory effects are based on modulation of gene expression at the transcriptional level. It achieves this effect through interaction with chromatin. The resulting activation and/or normalization of genes involved in cellular differentiation, proliferation, antioxidant defense, tight junction formation, and regulation of inflammatory pathways support the normal functioning of epithelial barriers, increase mucus clearance from the respiratory tract, promote secretory immunity and provide for rapid healing throughout all areas of both the lungs and the GI tract.

Because Chonluten may be used to study the lung/gut axis, chronic respiratory diseases (bronchitis/COPD), increased intestinal permeability (“leaky gut”), mucosal immunity, and inflammatory bowel disease; and because of its ability to regulate inflammatory mediator (TNF-alpha) production, oxidative stress response, and proliferative rate without suppressing the immune system broadly, Chonluten is especially useful as a pre-clinical model for studying chronic inflammation and tissue regeneration.

The Premium Chonluten Injector Pen provides 3 ml of 99%+ purity peptide in a convenient ready-to-use subcutaneous delivery device. This precise formulation is designed to provide accurate dosing and excellent bioavailability. Each device contains enough Chonluten to complete one experiment. Below you will find five benefits of Chonluten supported by peer-reviewed literature that describe the mechanistic basis of how Chonluten acts as a bioregulator.

1. Respiratory Epithelial Regeneration and Improved Mucociliary Function
Chonluten is able to normalize gene expression in bronchial epithelial cells allowing for proper cell development (differentiation), functioning of cilia and clearing mucus through the action of cilia – all functions that are typically compromised in chronic lung diseases.
It also plays a role in the restoration of damaged or stressed bronchial mucosa and allows for better organization of the layers of the epithelium.
Observational studies have shown and preclinical study results have indicated rapid recovery of the bronchial lining as well as reductions in senescent cells and improvements in the ability of tissues to withstand stress with respect to bronchitis and airway inflammation.

2. Reinforcement of the Gastrointestinal Mucosal Barrier
Chonluten increases the expression levels of tight junction proteins (e.g. zonula occludens and occludin) in the intestinal epithelium to strengthen the mechanical barrier and reduce paracellular permeability. Therefore, this may limit the migration of antigens from the lumen into systemic circulation through a reduction in the amount of luminal antigens that can cross the epithelial layer.
In experimental models where there is an increase in intestinal permeability, studies have shown chonluten’s potential in promoting epithelial repair and/or maintaining gut integrity during inflammation or with aging.

3. Enhancement of Coordinated Mucosal Immune Defense
Modulation of gene expression in both the lung and GI mucosa to enhance secretory IgA production, as well as innate immune sentry function and to promote a balance of the immune response at the first line of defense will be supported by chonluten. This will aid in optimizing local defenses to pathogens and harmful substances from the environment, while preventing systemic suppression of the immune system.
The dual-site immune modulation makes this product highly applicable to research on mucosal immunity, chronic recurring respiratory infections, and gut-lung immune cross-talk.

4. Potent Anti-Inflammatory Effects in Mucosal Tissues
The Chonluten reduces proinflammatory mediator activity (TNF-alpha, COX-2, etc.) and promotes the resolution of an inflammatory response at the level of the epithelium. Therefore, Chonluten is directed to promote healing and maintenance of tissue homeostasis rather than continue with chronic inflammatory signaling.
Studies using in vitro and in vivo models have demonstrated that Chonluten results in decreased inflammatory cell infiltration into tissues, less oxidative damage, and quicker resolution of inflammation in both the airways and intestines; therefore, this agent has potential use as a model to study chronic inflammatory mucosal diseases.

5. Harmonization of the Lung-Gut Axis
Chonluten is a compound that has two ways of influencing genes at the same time and can affect both the lungs and the gut. As such, this compound addresses the bi-directional relationship between the lungs and the gut, which are both components of the mucous membranes. The dysfunction of one component typically causes problems with the other; Chonluten supports systemic mucous membrane coherence and resistance.
Therefore, because of its ability to function as an integrated unit, Chonluten would be an excellent candidate for advanced research studies into relationships between the microbiome and mucosae, systemic inflammation, recovery from infection, and overall health of barriers (e.g., under conditions of aging or environmental stress).

Why Choose Our Chonluten Injector Pen?

Our chondroten (Chonluten) is supplied by established manufacturers and has undergone quality control third party testing for purity, strength, identification, and sterilization thereby meeting all of the standards necessary for reproducibility in mucosal/bioregulatory research. Due to its convenience and ease of use, our precision injector pen format provides uneventful delivery of accurately measured dosages of the chondroten via the subcutaneous route, maintains the drug in an optimal state, and minimizes drug waste. Therefore this product is well-suited for both acute and chronic research studies.

Regardless if you are conducting research regarding the repair of the respiratory epithelium, the intestinal barrier, the lung-gut axis, the role of anti-inflammatory responses to injury, or geroprotective effects at the level of the mucosa; Chonluten provides a targeted, epigenetically active bioregulator that has a solid foundation within the research conducted using peptides by Khavinson. Prior to implementing any protocol always obtain guidance from a licensed healthcare professional, research ethics committee, or institutional review board. All of these statements are supported by scientific literature and are provided as informative and educational material only. They should NOT be used to diagnose, treat, cure, or prevent ANY DISEASE.

Important Note: This product is intended strictly for research and laboratory use only. It is not for personal consumption, human or animal therapeutic use, or any clinical application. Please consult and fully comply with all local regulations in the UAE before purchasing or handling.