CARTALAX INJECTOR PEN 3ML

Cartalax (Ala-Glu-Asp / AED): The Targeted Musculoskeletal Bioregulator for Cartilage Renewal, Joint Health, and Connective Tissue Restoration — Now Available in the UAE

Cartalax, which can be identified through its scientific name, Ala-Glu-Asp (AED), is a novel form of the tripeptide as part of the class of short-chain bioregulators created by Prof. Vladimir Khavinson and his team at the St. Petersburg Institute of Bioregulation and Gerontology. Through an evaluation of amino acids from the peptides found in the natural cartilage and connective tissue, Cartalax was synthesized into a highly specific tripeptide that acts specifically upon chondrocytes, synovial cells, fibroblasts and osteoblasts that are involved in the musculoskeletal system.

In contrast to other forms of conventional joint supplements such as glucosamine, chondroitin or NSAIDS that usually address the symptomatology associated with joint issues or serve as a source of raw materials for joints; Cartalax operates at the epigenetic level. As such, it is capable of penetrating cellular nuclei, interacting with chromatin and restoring the proper regulation of gene expression to cartilage and connective tissue cells in instances where they have been damaged due to aging. This subsequently restores biosynthesis of key components of the extracellular matrix including proteoglycans (aggrecan) type II collagen and anti-catabolic factors while modulating local inflammation.

The resulting structural repair of articular cartilage, restored function of synovium and increased integrity of connective tissue makes Cartalax a unique tool for researchers who investigate the mechanisms of osteoarthritis (OA), age related joint degeneration, post traumatic repair of cartilage, tendinopathy, ligament strength, subchondral bone health and the broader applications of geroprotection directed towards the musculoskeletal system. The epigenetic mechanism of action of Cartalax provides a non hormonal, physiologic method for the study of joint aging and regeneration.

Our premium Cartalax injector pen contains a formulation of 3 ml of high purity (> 99%) peptide prepared under strict quality control guidelines. In addition to providing an easy to administer subcutaneously delivery vehicle for the peptide, our pen format also allows for both short term intense studies as well as longer cyclic studies and maintains the stability of the peptide.

Below, explore six key research-supported potential benefits of Cartalax, grounded in mechanistic preclinical data and Khavinson bioregulator science.

1. Stimulation of Cartilage Matrix Regeneration
Cartalax stimulates the expression of genes related to aggrecan, type II collagen, and other components of the extracellular matrix in chondrocytes. The result is a regrowth of cartilage and a recovery of the mechanical characteristics (thickness, resilience and shock absorbing) that are lost during joint degeneration or due to mechanical stress on joints. Khavinson et al., demonstrated an increase in proteoglycan production, as well as improvement in the histological arrangement of the cartilaginous matrix in explant cartilage cultures treated with musculoskeletal bioregulators, indicating a structural repair in models of joint degradation.

2. Improvement of Joint Mobility and Biomechanical Function
The biochemical recovery of the articular cartilage is assisted by peptidergic normalization of the synovial fluid; reduction of subchondral remodeling; and restoration of the morphological integrity of the cartilage surface. Peptide bioregulators help to restore functionally significant parameters (range of motion, bearing load) in aging joints. Studies conducted at the Institute for Bioregulation reported that after treatment with peptide bioregulators, older animals had significantly higher biomechanical parameters, were able to walk more normally and had greater stability within their affected joints.

3. Modulation of Local Inflammation in Articular and Synovial Tissue
The use of Cartalax has shown a reduction in the production of proinflammatory cytokine such as IL-1β and TNF-α along with MMPs produced by both synovial and cartilage tissues. This results in a reduction in the breakdown of cartilage but preserves the normal functioning of the immune system within the joint microenvironment. Studies utilizing an animal model of aging were performed to show that Cartalax could reduce the levels of inflammatory markers found in the lavage fluid obtained from joints. Therefore, Cartalax may be used to study chronic low grade joint inflammation without suppressing the entire immune response.

4. Enhancement of Collagen Synthesis and Connective Tissue Strength
Cartalax influences the behavior of fibroblasts within connective tissue (tendons, ligaments & peritendonous) by influencing the synthesis of Type I and Type III collagen and other extracellular matrix proteins to provide a balance for overall muscle-tendon support.

5. Counteraction of Age-Related Musculoskeletal Decline
The use of Cartalax has been shown to reactivate senescence-associated gene silencing for both chondrocytes and osteoblasts. This mechanism is thought to contribute to maintaining cartilage homeostasis, bone quality, as well as overall musculoskeletal health throughout a living organism’s biological aging process. Observations from longitudinal studies conducted on both primate and rodent models showed that there were no significant decreases in joint functionality; fewer (if any) signs of degeneration; and improved musculoskeletal performance indicators for animals receiving cartilage targeted bioregulator treatments over long-term time frames.

6. Support for Post-Trauma and Post-Injury Cartilage Repair
Cartalax promotes chondrocyte proliferation and remodelling of the matrix after a traumatic or post-surgical injury. This results in a quicker recovery from a functionally compromised state, as well as a reduced incidence of developing secondary osteoarthritis. The unique dual actions of both anabolism and catabolism by Cartalax makes this compound extremely relevant for studies into acute sports injuries, as well as other musculoskeletal trauma; recovery from orthopaedic procedures including micro-fracturing; and regenerative strategies to address articular cartilage defects.

Why Choose Our Cartalax Injector Pen?

The source for our Cartalax comes from reputable manufacturers with experience in the synthesis of peptides by Khavinson. Cartalax is also tested by independent third parties for purity, potency, identity, sterility, and stability. Each lot is tested against the high standards that must be met for reproducibility in sensitive musculoskeletal and joint research studies.

Our precision engineered injector pen design allows for easy administration via subcutaneous injection; it provides for precise dosing and minimizes waste while providing excellent storage stability. This design lends itself well to delivering consistent doses either as part of an every day or cycle-based regimen used in laboratories or other investigative environments.

Cartalax exemplifies the precision and tissue specificity of the Khavinson bioregulatory sciences. It acts at the epigenetic level on chondrocytes and connective tissues providing scientists with a sophisticated tool to study cartilage repair/formation, joint health and maintenance, and healthy musculoskeletal aging.

Before you initiate any treatment or use this product in your research, always consult a licensed healthcare professional, a research ethics committee or an Institutional Review Board. While these statements reflect information found in scientific literature they are only to provide information and education. None of these statements should be interpreted as diagnostic tools, treatments, cures or preventative measures for any disease.

Important Note: This product is intended strictly for research and laboratory use only. It is not for personal consumption, human or animal therapeutic use, or any clinical application. Please consult and fully comply with all local regulations in the UAE before purchasing or handling.