CARDIOGEN INJECTOR PEN 3ML

Cardiogen (Ala-Glu-Asp / AED): The Targeted Cardiac Bioregulator for Myocardial Renewal, Contractile Function, and Cardiovascular Resilience — Now Available in the UAE

The Khavinson group have synthesized Cardiogen as a tripeptide (Ala-Glu-Asp) that has demonstrated specific interaction with cardiac cells. Cardiogen was developed from an amino acid analysis of peptides in natural cardiac tissues. Unlike traditional drugs used to treat cardiovascular diseases, Cardiogen acts through modification of gene expression rather than acting on receptors or influencing blood flow.

In addition to other benefits, it induces changes in the expression of certain genes that are active in young hearts but remain dormant due to various forms of stress such as ischemia, oxidative stress, etc. Thus Cardiogen is able to promote regeneration of damaged heart muscle.

Cardiogen is also being studied as a potential therapeutic agent in the treatment of heart failure, myocardial infarction and cardiac hypertrophy, as well as other cardiovascular disorders.

We offer a 3 ml, pre-filled, sterile Cardiogen injector pen containing a highly purified (>99%), precisely formulated peptide. This product includes a ready-to-administer syringe for convenient use in research. The subcutaneous delivery method allows for accurate dosage administration and maximizes bioavailability to cardiac tissue. We provide a premium version of our Cardiogen product which is ideal for research applications involving acute and/or chronic studies of cardiovascular physiology.

Below, explore six key research-supported potential benefits of Cardiogen, grounded in mechanistic preclinical data and Khavinson bioregulator science.

1. Promotion of Cardiomyocyte Repair and Myocardial Regeneration
Cardiogen increases levels of differentiation and protective cardiogenic gene expressions in damaged or aged myocardium. In addition, it promotes expression of the contractile proteins actin and myosin as well as the maturation associated with cardiomyocytes which is important for restoring normal functioning of the myocardium through a reconstitution of the functional muscle mass of the heart. Linkova and colleagues also have shown that the Ala-Glu-Asp peptide resulted in significant elevations in the expression of differentiation markers and the functional ability of cardiomyocytes within cultures of cardiac tissue; thereby facilitating repair of damaged cardiomyocytes.

2. Acceleration of Post-Ischemic and Post-Infarction Recovery
Following a heart attack, Cardiogen has been shown to restore normal levels of certain “calcium-handling” proteins found in cardiomyocytes (such as SERCA2a), improve mitochondria in those cells that survive the damage from the heart attack; reduce expansion of the area of damaged tissue caused by the heart attack; and limit negative changes to how well the ventricles contract. Studies conducted by Khavinson’s group have demonstrated that Cardiogen-treated animals had better echocardiogram measurements compared to untreated controls; they also regained their cardiac output at an accelerated rate after having experienced a myocardial infarction model; and were noted to have less scarring around areas of the heart muscle where damage was incurred.

3. Normalization of Cardiac Rhythm and Electrical Stability
Cardiogen promotes the expression of gap junctions and ion channels (connexin-43) to enhance conduction velocities and reduce the substrate for arrhythmias while providing a stable electrophysiological environment during stress or in an aging heart. Research conducted by the Institute of Bioregulation demonstrated that ECG interval normalization along with reduced arrhythmia susceptibility was achieved in senescence-accelerated animal models utilizing cardiac bioregulatory agents.

4. Enhancement of Antioxidant Defense and Mitochondrial Protection in Cardiac Tissue
Cardiogen increases the expression of protective mitochondrial antioxidants such as SOD and catalase to reduce the cellular damage caused by the oxidative effects of both chronic metabolic stress and acute ischemia-reperfusion injury, thus helping protect against heart failure and cardiac aging. Pre-clinical research has shown that administration of Ala-Glu-Asp peptide formulations to aged subjects resulted in an increase of their antioxidant ability within their cardiac homogenate cells and a decrease in markers of oxidative stress.

5. Support for Coronary Endothelial Function and Vascular Tone
Cardiogen enhances gene expression in coronary endothelial cells to promote nitric oxide (NO) production; improve vasodilatory function of blood vessels; and reduce endothelial dysfunction — all are important in both the development of atherosclerosis (coronary artery disease), and in maintaining good cardiovascular health.

6. Prevention of Age-Related Cardiac Remodeling and Fibrosis
Cardiogen counters epigenetic drift and senescence in cardiomyocytes and fibroblasts, reducing excessive fibrosis, preserving myocardial compliance, and maintaining diastolic and systolic function during biological aging. These geroprotective effects position Cardiogen as a compelling tool for research on heart failure prevention, hypertensive heart disease, and strategies to extend cardiovascular healthspan.

Why Choose Our Cardiogen Injector Pen?

Our Cardiogen comes from suppliers that have been involved with the manufacture of peptides by the process developed by Dr. Khavinson and has undergone strict testing as well as third party verification in regards to its purity, potency, identify, sterility and stability. Each and every batch of Cardiogen will be tested and documented to meet all requirements needed to achieve reproducible results in studies utilizing sensitive cardiovascular and mitochondrial tissues.

The injector pen is precision engineered to provide the most convenient method for administering Cardiogen via subcutaneous injection. It allows for easy control over dosing while minimizing waste and providing the best possible storage stability. The injector pen is the perfect way to ensure consistency when delivering Cardiogen either at the same time each day or through a cyclical pattern in your lab or investigation setting.

Cardiogen is an example of how precise and targeted epigenetic regulation can occur within specific tissue types, such as the myocardium, which is typical of the focus offered through Khavinson’s Bioregulator Science. As a result, it represents a powerful tool for researchers interested in studying cardiac repair, rhythm stability, ischemic recovery and overall heart health during the process of normal aging.

Always consult with a qualified medical professional, research ethics committee or institutional review board prior to implementing any new study design. These comments are based upon published scientific data and are being presented strictly for informational/educational use only and should never be considered as medical advice intended to diagnose, treat, cure or prevent any type of illness.

Important Note: This product is intended strictly for research and laboratory use only. It is not for personal consumption, human or animal therapeutic use, or any clinical application. Please consult and fully comply with all local regulations in the UAE before purchasing or handling.