BRONCHOGEN INJECTOR PEN 3ML

Bronchogen (Lys-Glu-Asp / KED): The Targeted Bronchopulmonary Bioregulator for Respiratory Mucosal Renewal, Lung Function Restoration, and Age-Related Pulmonary Resilience — Now Available in the UAE

The use of bronchogen, also referred to as lysine-glutamic acid-aspartic acid (Lys-Glu-Asp) which represents an additional example of a tri-peptide and part of the Khavinson class of short chain bioregulators was first developed by Dr. Vladimir Khavinson and his group at the St. Petersburg Institute of Bioregulation and Gerontology. A unique aspect of bronchogen is its ability to be used in the treatment of damaged respiratory tissue based upon the initial study using broncho-pulmonary tissue from patients who had undergone lung surgery.

In addition to being a therapeutic agent, bronchogen has been studied extensively as a model for understanding how biologically active peptides are capable of modulating cellular behavior. Specifically, unlike other drugs that may act as anti-inflammatory compounds or agents that increase airway diameter through symptomatic relief; bronchogen acts at the epigenetic level. At this level it can penetrate into the nucleus of the cell and interact with chromatin thereby modifying the expression of genes in respiratory epithelial cells. As a result, these cells will again produce proteins that facilitate mucociliary clearance, protect them against oxidative stress caused by free radicals and other harmful substances, and assist in their own regeneration after injury due to such factors as smoking, infection or prolonged exposure to chemicals that damage lungs. Ultimately, this results in restored structure and function of the mucous lining covering the airways of the lungs and increased overall respiratory reserve without having systemic hormonal effects.

A primary benefit of bronchogen is that it provides researchers with a tool for conducting basic and translational research into various respiratory conditions including COPD (chronic obstructive pulmonary disease), recurrent bronchitis, bronchial asthma, environmentally and occupationally induced lung damage, post-infectious pulmonary fibrosis and age-related declines in respiratory function. Additionally, bronchogen’s ability to provide a specific mechanism for treating damaged respiratory tissue offers investigators a means for determining whether lung repair mechanisms have returned to normal over time and whether they remain functional.

The 3 ml injector pens we offer contain a highly purified (>99%), accurately measured amount of peptide that is contained within a sterile, pre-filled syringe. Because each injector pen is designed specifically for delivering the sub-cutaneously administered peptide directly to the target organ/tissue in question (i.e., the respiratory tract) all aspects of drug delivery are optimized (i.e., dose accuracy, bioavailability). Furthermore, our unique design allows investigators to easily conduct both short term/longitudinal studies as well as cyclic studies utilizing the same peptide preparation throughout the course of their investigation while maintaining the integrity/stability of the peptide.

Below, explore six key research-supporte potential benefits of Bronchogen, grounded in mechanistic preclinical data and Khavinson bioregulator science.

1. Restoration of Bronchial Mucosal Integrity and Mucociliary Clearance
Bronchogen is capable of normalizing (or to be correct, restoring) the structural organization of bronchial epithelium through facilitating appropriate differentiation of both ciliated and goblet cells. Thus, it restores effective mucociliary clearance — the lung’s main physical defense mechanism for clearing mucus and particulate matter from the airways while defending against pathogens.

2. Anti-Inflammatory Modulation in Respiratory Tissue
Bronchogen lessens an overabundance of pro-inflammatory cytokines (e.g., IL-1β, TNF-α and through NF-κB pathways) that are present in bronchial/alveolar tissues; it decreases neutrophilic inflammation along with edema. Furthermore, it allows for normal function of immune cells to be preserved in airways. Gerontological studies have demonstrated a reduction in inflammatory mediators within the bronchial lavage fluid and improvement in respiratory exchange variables as well as other pulmonary functions in geriatric animal models with chronic airway inflammation.

3. Enhancement of Antioxidant Defense in Lung Tissue
Bronchogen stimulates an increase of the body’s own antioxidant defenses that include the endogenous antioxidant enzymes SOD, Catalase and Glutathione Peroxidase in both alveolar and bronchiolar cells. The antioxidant defense system protects delicate lung tissue from oxidative damage due to pollution, cigarette smoke, infections, etc., and other types of cellular dysfunction. Studies were able to restore the activities of antioxidant enzymes in pulmonary tissues from senescence accelerated mice back to levels equal to those of healthy young control animals.

4. Support for Post-Infectious and Post-Injury Pulmonary Recovery
Bronchogen is a drug that can accelerate gene expression for regeneration in Type II Pneumocyte and Bronchial Epithelial cells to support more rapid repair of the alveoli, reduce residual fibrosis (fibrotic scarring), and enhance faster recovery of function post infection or ALI (acute lung injury).

5. Mitigation of Age-Related Respiratory Decline
Bronchogen preserves counteracts epigenetic repression that leads to cellular senescence within respiratory tissues; it supports the maintenance of alveolar surface area, elastic recoil and immune cell surveillance as well as the natural (and otherwise inevitable) decline in pulmonary function which occurs during the aging process. In addition, longitudinal studies of primate models demonstrated a preserved functional reserve for respiration and an extension of healthy span of the pulmonary system in aged subjects administered bronchopulmonary bioregulators.

6. Overall Improvement in Respiratory Homeostasis and Stress Resistance
Bronchogen is designed to provide a broad range of protective functions including support of lung function; protection from oxidative damage as well as inflammatory reactions that may compromise barrier function; and maintaining optimal oxygenation. These diverse mechanisms of action also make Bronchogen an appropriate candidate for studies investigating chronic obstructive pulmonary disease (COPD) pathology, asthma pathophysiology, occupational lung diseases and overall aging and its impact on lung function.

Why Choose Our Bronchogen Injector Pen?

Our Bronchogen has been produced by established suppliers that have considerable experience with Khavinson peptide manufacture. Therefore, it was tested rigorously using independent third party testing methods, which included testing for purity, potency, identity, sterility and stability. The manufacturer verifies each batch meets the high standard necessary to allow for the reproducibility needed in sensitive respiratory/pulmonary studies.

The precision engineered injector pen design allows for easy subcutaneous injection, precise dosing control, minimum loss and excellent storage stability. It is designed for use as part of routine and/or cyclic treatment schedules (daily) and/or in an investigative/ laboratory setting.

Bronchogen represents the best example of what can be achieved through precision and tissue specific approaches using Khavinson bioregulator peptides. Bronchogen acts at the epigenetic level on the bronchopulmonary tissues and will provide investigators with a novel method to study and understand mucosal repair, lung regeneration, inflammatory response resolution and the influence of age on healthy respiratory function.

Please seek consultation prior to commencing any new protocol with your qualified healthcare provider, research ethics committee or Institutional Review Board.

Important Note: This product is intended strictly for research and laboratory use only. It is not for personal consumption, human or animal therapeutic use, or any clinical application. Please consult and fully comply with all local regulations in the UAE before purchasing or handling.