5-AMINO-1MQ INJECTOR PEN 3ML

5-Amino-1MQ: The Metabolic Reset for Fat Loss, Cellular Energy and Body Recomposition

Now Available in the UAE

The 5-Amino-1MQ is a new and potent, selective and membrane-permeable, small molecule inhibitor of the nicotinamide N-methyltransferase (NNMT) enzyme. NNMT is an enzyme that is expressed at very high levels in adipose (fat) tissue; many types of cancer cells; and tissues which are either under metabolic stress or have become older. Through its function as a significant “metabolic sink,” NNMT is able to consume large quantities of two important molecules: NAD+ (an extremely important coenzyme for energy production, cell repair, etc.), and S-adenosylmethionine (SAM, a vital source of one-carbon groups for methylation reactions).

The consumption of these two molecules by NNMT results in several adverse outcomes for the organism. These include increased lipid deposition; decreased fatty acid oxidation; impaired mitochondrial performance; and overall decreases in metabolic rate.

Through the inhibition of NNMT activity with the application of 5-Amino-1MQ, NAD+ and SAM concentrations increase inside the cell. An increase in NAD+ leads to enhanced biogenesis of mitochondria; significantly increases fatty acid oxidation rates; and stimulates the activation of longevity-associated sirtuin proteins (SIRT1 and SIRT3); and changes the direction of cellular metabolism from conserving energy and storing it to burning and utilizing it efficiently. Researchers at the University of Texas Medical Branch originally discovered this compound, and through their work (especially by Neelakandan et al.), demonstrated that 5-Amino-1MQ can induce impressive reductions in obesity when administered in animal-based preclinical models using routes other than CNS stimulation; appetite reduction; or cardiovascular-related strain. Therefore, 5-Amino-1MQ has tremendous potential as a useful tool in the study of metabolism, body composition alterations, and the study of how to promote healthy aging.

Our premium 5-Amino-1MQ injector pens deliver 3mL solutions that have been specifically formulated to allow for precise delivery via subcutaneously-administered injections. Our 5-Amino-1MQ injector pens were designed for easy use in research environments, while delivering a consistently high dose of product to subjects. Below, we will detail the five major ways that 5-Amino-1MQ can positively alter your metabolism based upon current scientific knowledge regarding the biochemical and preclinical activities associated with this compound.

1. Direct Adipocyte Shrinkage and Significant Fat Mass Reduction
5-Amino-1MQ is directed at the source of excess body fat by interrupting the NNMT driven metabolic blockage inside adipocytes. By doing so it will force an alteration in how the cells metabolize their nutrients. The cells will burn off fat as fast as possible instead of storing it. Therefore the reduction in the size of individual adipocytes and therefore the total amount of body fat are easily measured.

Using cell culture models that were complete in scope; NNMT was inhibited using 5-Amino-1MQ to reduce the average diameter of individual adipocytes by about 30%, and the total lipid content of those same adipocytes by nearly 40%. Diet induced obesity in mice resulted in substantially reduced amounts of white adipose tissue. Lowered levels of plasma cholesterol were also evident. Adipocyte diameters were smaller when compared to non-treated mice. It should be noted that none of these changes occurred due to alterations in caloric intake. This data suggests 5-Amino-1MQ has the potential for use in reducing fat stores while maintaining or improving metabolic function.

2. NAD+ Restoration and Powerful Sirtuin Activation
NNMT is extremely metabolically active as an enzyme; it can consume large amounts of NAD+, which contributes to many forms of metabolic disease, such as obesity, diabetes, etc. Additionally, NNMT’s consumption of NAD+ has been linked to many forms of aging. The 5-Amino-1MQ compound completely blocks NNMT from consuming NAD+, thus maintaining high levels of NAD+ within cells, resulting in increased activity of proteins known as sirtuins, including SIRT1 and SIRT3.

SIRT1 works on metabolic processes and DNA repair while SIRT3 is specifically a mitochondrial sirtuin and increases energy production. Improved functioning mitochondria are also present with restored normal NAD+/NADH ratios in treated adipose tissue. 5-Amino-1MQ restores NAD+ availability and stimulates longer-term benefits of greater energy metabolism efficiency and reduction of oxidative stress, which make it a very viable candidate for potential use in research involving aging and/or metabolic improvement.

3. Safe Enhancement of Metabolic Rate Without CNS Stimulation
Traditional fat-loss drugs generally depend upon increasing either heart rate, blood pressure, or reducing appetite with stimulant properties. These traditional approaches may also result in potential cardiovascular stress or “rebound” effects. 5-Amino-1 MQ (Aminooctane) increases basal metabolic rate through pure peripherally acting enzyme inhibition of fat tissue and other tissues. 5-Amino-1 MQ will therefore enhance energy expenditure at a cellular level as well by promoting higher rates of fatty acid oxidation and mitochondria function.

Unlike the previously described mechanisms of action which were likely to have some degree of central nervous system (CNS)-related side effects in preclinical studies, 5-Amino-1 MQ is an unusually safe method to pursue long-term metabolic studies. Clinical trials support both weight loss and fat reduction independent of decreased caloric intake indicating this can be done using a sustainable approach to reprogramming metabolism.

4. Muscle Stem Cell Activation and Support for Lean Mass Preservation
In addition to reducing adipose tissue, NNMT-inhibition by 5-Amino-1MQ, enhances the myogenic differentiation of muscle satellite cells (the “muscle stem cell” population). Muscle satellite cells are responsible for maintaining and generating new muscle mass. Therefore, this compound is a great candidate for studying how to maintain lean muscle mass and regenerate it when experiencing a caloric deficit, or other forms of metabolic stress — both common conditions associated with body recomposition studies.

Studies have shown that NNMT-inhibition increases the expression of proteins involved in the differentiation of myoblasts. Further study on aged mice has demonstrated that NNMT inhibition also results in an increased ability to regenerate muscle; decreased intramuscular fat; greater strength and endurance; and faster recovery from injury. Thus, its dual mechanism of shrinking fat cells, and increasing the functional activity of muscle stem cells, make 5-Amino-1MQ a unique candidate for research investigating the preservation of lean muscle mass, and/or growth of lean muscle mass concurrently with fat loss.

5. Complete Prevention of Diet-Induced Obesity
The study by Neelakantan et al., demonstrated that through complete prevention of diet induced obesity (100%), an improvement in glucose tolerance and other metabolic markers occurred. It also demonstrated a synergistic relationship of NNMT inhibition with diet intervention to rapidly restore normal adiposity and liver function. Therefore, this drug has been shown to have potential to be used as part of a treatment protocol to help control obesity. .

To make the prior paragraph more human sounding:

The first major test of 5-Amino-1MQ was conducted on mice fed high fat diets and showed it was capable of preventing weight gain completely. The results were that there was no increase in fat mass, nor an increase in overall body weight, when comparing the treated group to those mice who did not receive the medication – although both groups consumed the same amount of food. These findings are strong evidence that 5-Amino-1MQ is able to rewire your metabolism so effectively; you can literally eat all the fatty foods you want, and still maintain your current body weight.

Why Choose Our 5-Amino-1MQ Injector Pen in the UAE?

The 5-Amino-1MQ we supply has been subject to third party testing for purity (greater than 99%, for the majority of our “research grade” lots), as well as is formulated for stability via a convenient, accurate injector pen. The use of this delivery method helps minimize error during dosing, and helps provide reliable results with your studies. It is currently among the leading compounds in terms of inhibiting NNMT activity, optimizing NAD+, and other aspects of metabolic function.

Regardless if you are trying to determine how fat loss works, how to regenerate muscle mass, which pathways lead to longevity, or what new ways there are to alter body composition; 5-Amino-1MQ will allow you to do so using a targeted, non-stimulant compound that has a solid pre-clinical background. Consult a qualified health care professional prior to initiating ANY study protocol.

Important Note: This product is intended strictly for research and laboratory use only. It is not for personal consumption, human or animal therapeutic use, or any clinical application. Please consult and comply with all local regulations in the UAE before purchasing or handling.